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Sedatives: Summary of affordable alternatives
Four drugs used to treat insomnia – zolpidem (Ambien and Ambien CR), eszopiclone (Lunesta), ramelteon (Rozerem), and zaleplon (Sonata) – have been widely promoted to both doctors and consumers over the past two years.
drug reportWhile effective, these medicines are not necessarily better than older, less expensive drugs for many people who need a sleep aid for a night or two. For example, non–prescription drugs containing antihistamines (Benadryl, Nytol, Sominex, Tylenol PM, and Unisom) and older prescription sedatives called benzodiazepines may work just as well. Among the benzodiazepines approved as sleep aids are estazolam (ProSom), flurazepam (Dalmane), and temazepam (Restoril).

However, we recommend that both the older and newer sleeping pills be taken more judiciously and less often than appears to be the current pattern of use by millions of people in the U.S. There are two main reasons for that advice:

  • People with only mild insomnia problems may be relying too heavily on pills and not trying to address their sleep problems with non–drug measures.
  • All sleeping medicines have side effects, can cause dependency, and even worsen insomnia problems when abused, misused, or taken too often. The side effects include daytime sleepiness, cognitive impairment, dizziness, unsteadiness, and rebound insomnia. Sleep–walking, sleep–driving, memory lapses, and hallucinations have also been reported.

People with persistent, chronic insomnia — three or more nights a week for months on end — do need treatment. We advise behavioral therapy that improves sleep habits, possibly combined with cautious use of sleeping pills.

If you and your doctor have decided that you need a sleeping pill, we recommend you use it for the shortest period possible. Based primarily on the fact that it will soon become a less expensive generic, we have chosen zolpidem (Ambien) as the Consumer Reports Best Buy Drug.

Fifteen doses of Ambien now costs around $58. When generic zolpidem becomes available that price should decline by 50% to 70%.

Newer Insomnia Drugs and Selected Older Ones: Cost Comparison and Best Buy Drugs
Recommendations: Newer Insomnia Drugs
CR Best Buy Generic Name Brand Name Is a Generic Drug? Average Cost for 7 Doses1 Average Cost for 15 Doses1 Compare
Prices
Newer Sedatives
CR Best Buy Zolpidem tablet 10mg tablet Ambien Yes2 $31 $67 Compare Prices
CR Best Buy Zolpidem tablet 5mg tablet Ambien Yes2 $32 $68 Compare Prices
  Zolpidem 6.25mg sustained release Ambien CR No $29 $62 Compare Prices
  Zolpidem 12.5mg sustained release Ambien CR No $29 $61 Compare Prices
  Eszopiclone 1mg tablet Lunesta No $32 $70 Compare Prices
  Eszopiclone 2mg tablet Lunesta No $32 $69 Compare Prices
  Eszopiclone 3mg tablet Lunesta No $32 $69 Compare Prices
  Ramelteon 8mg tablet Rozerem No $26 $56 Compare Prices
  Zaleplon 5mg capsule Sonata No $29 $61 Compare Prices
  Zaleplon 10mg capsule Sonata No $31 $65 Compare Prices
Selected Antidepressants
  Trazodone 50mg Desyrel No $18 $39 Compare Prices
  Trazodone 100mg Desyrel No $29 $62 Compare Prices
  Trazodone 150mg Desyrel No $28 $60 Compare Prices
  Trazodone 50mg Generic Yes $3 $6 Compare Prices
  Trazodone 100mg Generic Yes $3 $7 Compare Prices
  Trazodone 150mg Generic Yes $5 $12 Compare Prices
Selected Benzodiazepines3
  Estazolam 1mg tablet ProSom No $13 $27 Compare Prices
  Estazolam 2mg tablet ProSom No $14 $30 Compare Prices
  Estazolam 1mg tablet Generic Yes $6 $13 Compare Prices
  Estazolam 2mg tablet Generic Yes $7 $15 Compare Prices
  Flurazepam 15mg capsule Dalmane No $15 $32 Compare Prices
  Flurazepam 30mg capsule Dalmane No $15 $33 Compare Prices
  Flurazepam 15mg capsule Generic Yes $3 $6 Compare Prices
  Flurazepam 30mg capsule Generic Yes $3 $7 Compare Prices
  Lorazepam 0.5mg tablet Ativan No $9 $20 Compare Prices
  Lorazepam 1mg tablet Ativan No $12 $26 Compare Prices
  Lorazepam 2mg tablet Ativan No $18 $39 Compare Prices
  Lorazepam 0.5mg tablet Generic Yes $3 $7 Compare Prices
  Lorazepam 1mg tablet Generic Yes $4 $8 Compare Prices
  Lorazepam 2mg tablet Generic Yes $5 $10 Compare Prices
  Quazepam 7.5mg tablet Doral No $23 $50 Compare Prices
  Quazepam 15mg tablet Doral No $32 $69 Compare Prices
  Temazepam 7.5mg capsule Restoril No $29 $62 Compare Prices
  Temazepam 15mg capsule Restoril No $38 $82 Compare Prices
  Temazepam 30mg capsule Restoril No $42 $90 Compare Prices
  Temazepam 7.5mg capsule Generic Yes $9 $19 Compare Prices
  Temazepam 15mg capsule Generic Yes $3 $7 Compare Prices
  Temazepam 30mg capsule Generic Yes $4 $8 Compare Prices
  Triazolam 0.125mg tablet Halcion No $12 $25 Compare Prices
  Triazolam 0.25mg tablet Halcion No $13 $28 Compare Prices
  Triazolam 0.125mg tablet Generic Yes $5 $10 Compare Prices
  Triazolam 0.25mg tablet Generic Yes $5 $11 Compare Prices
(1) Recommended use is one pill at bedtime. The prices given are based on per pill costs. Prices reflect nationwide retail average for September 2006, rounded to the nearest dollar. Prices are derived by Consumer Reports Best Buy Drugs from data provided by Wolters Kluwer Health, Pharmaceutical Audit Suite.

(2) The FDA gave tentative approval to two generic versions of zolpidem in October 2006. These drugs should be on the market in the next few months. If you have a prescription for Ambien, be sure to ask your doctor or pharmacist to change it to generic zolpidem when it becomes available.

(3) Those approved by the FDA for treating insomnia. Other benzodiazepines that act in the same way are also available but their makers have not sought approval for use in the treatment of insomnia. These other benzodiazepines may be prescribed off-label for that purpose by some doctors.
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