Autism

What is autism?
You may have noticed that your child was different, even as a small baby. Perhaps they seem less involved with the world around them than other children. And may be your child doesn't show much interest in people.
You may be trying to work out whether the differences you have noticed are autism. Or you may have been told that your child
has autism and want to find out the best way to help them.
- If your child has autism, they may not learn to speak at the usual age. And they may have problems communicating in other ways too.
- Also, your child may not be interested in other people. And they may have set ways of behaving and may do the same activity over and over again.
- Usually, these signs show up before your child is 3 years old.
- We don't know what causes most cases of autism. But it's linked to how your child's brain works. It's not caused by anything you as a parent might have done.
- About 6 in 1,000 children have an autistic spectrum disorder. That means they have autism or a related condition. Some children have only mild symptoms and some children have bad symptoms.
- There isn't any cure for autism. Your child will always have it. But getting treatment early on can help make a difference to your child's life.
Source:
Volkmar FR, Pauls D.
Autism.
Lancet. 2003; 362: 1133-1141.
1 - There hasn't been much good research on which treatment works best.

Children with autism usually grow and look like other children but they don't develop the skills to get along with other children.
But they grow in other important ways too. They learn how to speak, smile and get along with people in other ways, such as
playing. Doctors call all of these changes development. These changes normally happen by specific ages. So you may hear them called developmental milestones. A milestone is just a way to tell how far you have come.
Doctors watch for milestones to tell whether your child is developing properly. You can watch for them too. If you are worried
about your child having autism, here are some milestones you can watch for.
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5
Source:
U.S. National Library of Medicine.
Medline Plus: developmental milestones.
October 2007. Available at http://www.nlm.nih.gov/medlineplus/ency/article/002348.htm (accessed on 21 April 2009).
U.S. National Library of Medicine.
Medline Plus: developmental milestones.
October 2007. Available at http://www.nlm.nih.gov/medlineplus/ency/article/002348.htm (accessed on 21 April 2009).
Source:
Committee on Children with Disabilities.
Technical report: the pediatrician's role in the diagnosis and management of autistic spectrum disorder in children.
Pediatrics. 2001; 107: 85.
Committee on Children with Disabilities.
Technical report: the pediatrician's role in the diagnosis and management of autistic spectrum disorder in children.
Pediatrics. 2001; 107: 85.
Source:
American Academy of Neurology and Child Neurology Society.
Practice parameter: screening and diagnosis of autism.
Available at http://www.guidelines.gov (accessed on 21 April 2009).
American Academy of Neurology and Child Neurology Society.
Practice parameter: screening and diagnosis of autism.
Available at http://www.guidelines.gov (accessed on 21 April 2009).
Source:
Johnson CP.
New tool helps primary care physicians diagnose autism early.
AAP News. 2004; 24: 74.
Johnson CP.
New tool helps primary care physicians diagnose autism early.
AAP News. 2004; 24: 74.
- By the age of 2 months, most babies smile.
- By 9 months, most babies follow your finger if you point to something.
- By 1 year, most babies babble and point to things they want.
- By 2 years, most babies can speak phrases of two words on their own (not copying their parents) and can play pretend.
Skills such as speaking, smiling and getting on are controlled by your brain. It does this through several networks or pathways of nerves that connect your brain to other parts of your body. As your child grows their brain forms new pathways so they develop more
skills.
With autism, your child's brain doesn't work as it should.
1This affects how your child develops in many ways. So doctors call autism a pervasive developmental disorder (PDD for short).
Source:
Volkmar FR, Pauls D.
Autism.
Lancet. 2003; 362: 1133-1141.
Volkmar FR, Pauls D.
Autism.
Lancet. 2003; 362: 1133-1141.
On the outside, children with autism usually grow and look like other children. But they don't develop the skills they need
to get along well with others or to keep up in school.
With autism, your child usually has problems with speaking. And they may not like being touched in any way, such as cuddling. Also, they may behave in odd ways. For example, your child
may do the same activity over and over again. Or they may follow the same routine all the time.
Sometimes, children with autism are very good at a certain skill or subject, such as math, technical drawing or music. That's
because they can focus very hard on just one thing. This is linked to their autism. But this happens rarely.
Autism affects different children in different ways. Some children never learn to speak and need help throughout their life.
Other children can learn the skills they need to live on their own.
Autism belongs to a group of similar conditions. Doctors call this group autistic spectrum disorder. The group also includes a condition called Asperger's syndrome. To learn more, see Autistic spectrum disorder.
On these pages, we are looking at autism itself.
If your child has autism, you may worry that something you did caused it. But nothing you have done as a parent could have caused your child's autism.
In most children with autism, doctors don't know the exact cause for it.
6 All we know is that the brains of children with autism work in a different way.
1
Source:
Folstein SE.
Autism.
International Review of Psychiatry. 1999; 11: 4.
Folstein SE.
Autism.
International Review of Psychiatry. 1999; 11: 4.
Source:
Volkmar FR, Pauls D.
Autism.
Lancet. 2003; 362: 1133-1141.
Volkmar FR, Pauls D.
Autism.
Lancet. 2003; 362: 1133-1141.
Researchers have looked at many factors to see whether they are linked to autism. We've described some of these below.
Studies give us good evidence that autism is mainly caused by
genes, rather than by any things your baby or child experiences. You get half of your genes from your father and half from your
mother. Your genes control how your body develops. If you have a faulty gene, it can cause problems with growth and health.
But this doesn't always happen.
genes
Your genes are the parts of your cells that contain instructions for how your body works. Genes are housed on chromosomes, structures that sit in the nucleus at the middle of each of your cells. You have 23 pairs of chromosomes in your normal cells, each of which has thousands of genes. You get one set of chromosomes, and all of the genes that are on them, from each of your parents.
Your genes are the parts of your cells that contain instructions for how your body works. Genes are housed on chromosomes, structures that sit in the nucleus at the middle of each of your cells. You have 23 pairs of chromosomes in your normal cells, each of which has thousands of genes. You get one set of chromosomes, and all of the genes that are on them, from each of your parents.
A combination of certain faulty genes from both parents may increase a child's chance of getting autism. We're still not sure which genes
are involved or how the faulty genes affect your child's brain. We have good evidence from research that autism is mainly
caused by genes.
- Some studies have looked at autism in families. When a family has one child with autism, the chance of having another child with autism are about 1 in 20.
Source:
Bolton P, Macdonald H, Pickles A, et al.
A case-control family history study of autism.
Journal of Child Psychology and Psychiatry. 1994; 35: 877-900.
7 This is much higher than we would expect.Source:
Folstein SE.
Autism.
International Review of Psychiatry. 1999; 11: 4.
6 - Other studies have looked at identical twins. Identical twins have the same genes. These studies have shown that if one twin
has autism, there is a 6 in 10 to 9 in 10 chance that the other twin also has autism.
Source:
Lamb JA, Parr JR, Bailey AJ, et al.
Autism: in search of susceptibility genes.
Neuromolecular Medicine. 2002; 2: 11-28.
8 This is a much higher chance than for nonidentical twins. Nonidentical twins don't have the same genes.
The genes your child has may not be the only reason for their autism. Things your child goes through in the womb, at birth
or afterward, might help bring on the condition. Autism probably happens because of a combination of genes and these other things. But researchers haven't found any good evidence for this. So we can't say for sure.
9
Source:
Medical Research Council.
MRC review of autism research: epidemiology and causes.
December 2001. Available at http://www.mrc.ac.uk (accessed on 21 April 2009).
Medical Research Council.
MRC review of autism research: epidemiology and causes.
December 2001. Available at http://www.mrc.ac.uk (accessed on 21 April 2009).
Some studies have shown that babies born prematurely, or with very low birth weights, are more likely to have autism.
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11
Source:
Kolevzon A, Gross R, Reichenberg A.
Prenatal and perinatal risk factors for autism: a review and integration of findings.
Archives of Pediatrics and Adolescent Medicine. 2007; 161: 326-333.
Kolevzon A, Gross R, Reichenberg A.
Prenatal and perinatal risk factors for autism: a review and integration of findings.
Archives of Pediatrics and Adolescent Medicine. 2007; 161: 326-333.
Source:
Schendel D, Bhasin TK.
Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities.
Pediatrics. 2008; 121: 1155-1164.
Schendel D, Bhasin TK.
Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities.
Pediatrics. 2008; 121: 1155-1164.
Sometimes autism is caused by a medical condition that your child gets. But this isn't common.
8 In about 1 in 10 children with autism, the autism is clearly caused by a medical condition.
9 To learn more, see Medical causes of autism.
Source:
Lamb JA, Parr JR, Bailey AJ, et al.
Autism: in search of susceptibility genes.
Neuromolecular Medicine. 2002; 2: 11-28.
Lamb JA, Parr JR, Bailey AJ, et al.
Autism: in search of susceptibility genes.
Neuromolecular Medicine. 2002; 2: 11-28.
Source:
Medical Research Council.
MRC review of autism research: epidemiology and causes.
December 2001. Available at http://www.mrc.ac.uk (accessed on 21 April 2009).
Medical Research Council.
MRC review of autism research: epidemiology and causes.
December 2001. Available at http://www.mrc.ac.uk (accessed on 21 April 2009).
In the past, some experts thought that vaccination with the MMR vaccine (a vaccine for measles, mumps and rubella) might be
linked to autism. Because of the worry, many parents have decided not to give their children this vaccine. But several big
studies have looked into this question. All these studies have said there isn't any evidence of a link between the MMR vaccine and autism.
Leading researchers and doctors who specialize in child health advise parents to give their children the MMR vaccine.
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14
Source:
Lamb JA, Parr JR, Bailey AJ, et al.
Autism: in search of susceptibility genes.
Neuromolecular Medicine. 2002; 2: 11-28.
Lamb JA, Parr JR, Bailey AJ, et al.
Autism: in search of susceptibility genes.
Neuromolecular Medicine. 2002; 2: 11-28.
Source:
Institute of Medicine of the National Academies.
Immunization safety review: measles-mumps-rubella vaccine and autism.
National Academies Press, Washington DC, U.S.A.; 2001.
Institute of Medicine of the National Academies.
Immunization safety review: measles-mumps-rubella vaccine and autism.
National Academies Press, Washington DC, U.S.A.; 2001.
Source:
Wilson K, Mills E, Ross C, et al.
Association of autistic spectrum disorder and the measles, mumps, and rubella vaccine: a systematic review of current epidemiological evidence.
Archives of Pediatrics and Adolescent Medicine. 2003; 157: 628-634.
Wilson K, Mills E, Ross C, et al.
Association of autistic spectrum disorder and the measles, mumps, and rubella vaccine: a systematic review of current epidemiological evidence.
Archives of Pediatrics and Adolescent Medicine. 2003; 157: 628-634.
Source:
Drug and Therapeutics Bulletin.
MMR vaccine: how effective and how safe?
Drug and Therapeutics Bulletin. 2003; 41: 25-29.
Drug and Therapeutics Bulletin.
MMR vaccine: how effective and how safe?
Drug and Therapeutics Bulletin. 2003; 41: 25-29.
To learn more, see MMR vaccine and autism.
Sources for the information on this page:
- Volkmar FR, Pauls D.Autism.Lancet. 2003; 362: 1133-1141.
- U.S. National Library of Medicine. Medline Plus: developmental milestones.October 2007. Available at http://www.nlm.nih.gov/medlineplus/ency/article/002348.htm (accessed on 21 April 2009).
- Committee on Children with Disabilities.Technical report: the pediatrician's role in the diagnosis and management of autistic spectrum disorder in children.Pediatrics. 2001; 107: 85.
- American Academy of Neurology and Child Neurology Society.Practice parameter: screening and diagnosis of autism.Available at http://www.guidelines.gov (accessed on 21 April 2009).
- Johnson CP.New tool helps primary care physicians diagnose autism early.AAP News. 2004; 24: 74.
- Folstein SE.Autism.International Review of Psychiatry. 1999; 11: 4.
- Bolton P, Macdonald H, Pickles A, et al.A case-control family history study of autism.Journal of Child Psychology and Psychiatry. 1994; 35: 877-900.
- Lamb JA, Parr JR, Bailey AJ, et al.Autism: in search of susceptibility genes.Neuromolecular Medicine. 2002; 2: 11-28.
- Medical Research Council.MRC review of autism research: epidemiology and causes.December 2001. Available at http://www.mrc.ac.uk (accessed on 21 April 2009).
- Kolevzon A, Gross R, Reichenberg A.Prenatal and perinatal risk factors for autism: a review and integration of findings.Archives of Pediatrics and Adolescent Medicine. 2007; 161: 326-333.
- Schendel D, Bhasin TK.Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities.Pediatrics. 2008; 121: 1155-1164.
- Institute of Medicine of the National Academies.Immunization safety review: measles-mumps-rubella vaccine and autism.National Academies Press, Washington DC, U.S.A.; 2001.
- Wilson K, Mills E, Ross C, et al.Association of autistic spectrum disorder and the measles, mumps, and rubella vaccine: a systematic review of current epidemiological evidence.Archives of Pediatrics and Adolescent Medicine. 2003; 157: 628-634.
- Drug and Therapeutics Bulletin.MMR vaccine: how effective and how safe?Drug and Therapeutics Bulletin. 2003; 41: 25-29.
This information was last updated on May 01, 2009
This information is for educational use only, and is not a substitute for prompt professional medical advice. Readers should always consult a physician or other professional for advice and treatment.
© BMJ Publishing Group Limited 2009. All rights reserved.
© BMJ Publishing Group Limited 2009. All rights reserved.
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