What is Migraine in adults?

Migraine in adults

What are migraines?

If you have been diagnosed as having migraines, you probably already know how much they can affect your life. A migraine attack can be so severe that it stops you getting on with life. An attack can feel like more than just a headache. You may feel odd beforehand, see dots or flashing lights, get pins and needles, or feel queasy or vomit.

There's no cure that can stop you getting migraines, but they can be treated. Lots of people cope well with migraines for many years, by taking medicine that stops the symptoms of an attack.

The pain from migraines can stop you from going about your daily life.

Having migraines doesn't mean something is seriously wrong with your brain. Scientists now think that in people who get migraines, part of their brain is more excitable than normal. Because of this, the brain releases high levels of chemicals called

neurotransmitters
Neurotransmitters are chemicals that help to carry messages between nerve cells. Serotonin, dopamine and noradrenaline are all neurotransmitters.

neurotransmitters. These make the blood vessels in your brain dilate (get wider) and sometimes get

inflammation
If your skin or some other part of your body becomes red, swollen, hot or sore, we say it is inflamed. It means that your body is trying to protect you from germs, from something in your body tissues that can hurt you (like a thorn or sliver), or from things that cause allergies (allergens). Inflammation is part of the way the body heals an infection or injury.

inflamed. This is what causes the pain of migraines.

Key points for people with migraines

Migraine attacks are severe headaches that last from four to 72 hours.
You may also have other symptoms, such as feeling sick or being extra-sensitive to sound or light.
About 1 in 6 people who have migraines get what's called an

auras
Auras are short-term changes in the way your nerves work. The changes happen before some migraine headaches, fits (seizures) or other problems with your nervous system. If you have an aura, you may see flashing lights, have blind spots (areas that you can't see) or get ringing in your ears. Some people get numbness or pins and needles in parts of their body. Others have trouble speaking or feel distant from people around them.

aura. This can cause temporary problems with your vision or pins and needles or numbness in parts of your body.
You may be more likely to get a migraine attack if you are tired, hungry or stressed, or eat or drink certain foods.
Aspirin can help if your pain is not too bad. For extra relief, you can try taking a pill that has aspirin, acetaminophen and caffeine. The brand name for this is Excedrin Migraine.
Ibuprofen also works for migraines, but you may need the higher dose, which you can get only with a doctor's prescription.
Triptans are drugs that work quickly to make you feel better. They can help if you have bad attacks, but they do have side effects. And they don't work for everyone.
If you get migraine attacks often, talk to your doctor about medication to prevent them. To learn more see Treatments to prevent migraine.

Is my headache a migraine?

A group of headache specialists called the International Headache Society say that you're having a migraine if your headache lasts between four and 72 hours and you have two of the symptoms listed below:

Source:
Goadsby PJ, Lipton RB, Ferrari MD.
Migraine: current understanding and treatment.
New England Journal of Medicine. 2002; 346: 257-270.

The pain is on one side of your head (this is called unilateral pain)
The pain is a throbbing pain
The pain gets worse when you move
The pain is moderate or severe. If your pain is moderate, you may be able to keep working, but only half as well as you would normally. If your pain is severe, you usually need to go to bed.

If you have a migraine attack, you will also have one or more of the symptoms in this list:

Source:
Goadsby PJ, Lipton RB, Ferrari MD.
Migraine: current understanding and treatment.
New England Journal of Medicine. 2002; 346: 257-270.

You may feel nauseated or have an upset stomach, or you may throw up
You may be extra-sensitive to light (photophobia)
You may be extra-sensitive to sounds (phonophobia).

Different types of migraine: with or without auras

About 1 in every 6 people who have migraines also have temporary problems with their vision (usually lasting an hour or less) or feel pins and needles or numbness in parts of their body.

Source:
Goadsby PJ, Lipton RB, Ferrari MD.
Migraine: current understanding and treatment.
New England Journal of Medicine. 2002; 346: 257-270.

¹ You may also find that you cannot move parts of your body normally.

These things usually happen before you get a migraine headache, and they are called migraine auras. The aura is a warning of an attack and can be frightening. To learn more, see What causes auras?

How often will I get migraines?

No one can say how often you will get migraines, but the average is slightly more than one a month.

Source:
Goadsby PJ, Lipton RB, Ferrari MD.
Migraine: current understanding and treatment.
New England Journal of Medicine. 2002; 346: 257-270.

¹ Some people get them as often as once a week and others get them much less often.

What causes migraines?

Researchers think that migraines are caused by a problem that makes some cells in your brain more excitable than normal.

Source:
Tepper SJ, Donnan GA, Dowson AJ, et al.
A long-term study to maximise migraine relief with zolmitriptan.
Current medical research and opinion. 1999; 15: 254-271.

² It doesn't mean there's something wrong with your brain. To understand what causes your attacks, you may find it helpful to learn a bit about what your brain does and why it does it. To find out more, see What does your brain do?

Researchers are using new types of scanners to see what happens in the brain when someone has a migraine attack.

Source:
Goadsby PJ, Lipton RB, Ferrari MD.
Migraine: current understanding and treatment.
New England Journal of Medicine. 2002; 346: 257-270.

¹ One of these new types of scanners is a position emission tomography scan, or PET scan for short. This scan picks up the electrical and chemical changes that happen in the brain.

Researchers believe that there is a pain center at the base of the brain.
If you get migraine attacks, you probably have a more sensitive pain center than other people do. This means that your pain center is overexcited by things that wouldn't bother someone else, such as bright lights or tiredness.
The nerve cells in this center react by telling the blood vessels in certain areas of the brain to open up (dilate). The walls of your blood vessels are slightly elastic, so they can get bigger to let more blood through or get narrower to let less blood through.
When the blood vessels open up, nerves in the walls of the blood vessels release chemicals (called neurotransmitters) that make the vessels open up even more. These chemicals make the blood vessels inflamed. This is what causes the throbbing pain of a migraine attack.
Migraine headaches can be so bad that they affect your sympathetic nervous system. This is the part of your nervous system that you have no control over. It gets your body ready to run away or fight any threat that comes along: in this case, a bad headache. In a migraine attack the effect on this part of your nervous system can make you feel sick, vomit or have diarrhea.
When your sympathetic nervous system is affected, the activity in your gut may slow down, so it takes longer for the food that you have eaten to leave your stomach. And it also takes longer for any pills that you have taken to be digested and get into your blood. This is one reason why some treatments for migraine sometimes don't seem to work.
Your sympathetic nervous system also makes the blood vessels in your skin get narrower, so you look pale. It can also make you more sensitive to what is going on around you, so that lights, noises or smells are hard to bear.

What causes migraine auras?

Migraine auras seem to be caused by a wave of electrical nerve impulses (excitation) travelling slowly across part of your brain. This is followed by a long period of underactivity in this area.

If you have auras, this underactivity results in reduced action in the part of your body controlled by that section of your brain. The back of your brain, which controls your eyes, is most often affected. This explains why your eyes see only part of what they are looking at. When the areas of your brain that are affected are the ones that control how your body feels, you may feel numb in one part of your body.

What can trigger a migraine attack?

You may find that certain things can set off your migraine attacks. These are called migraine triggers. Different people have different triggers. But it is often hard to work out what the triggers are. There isn't much research on this, but common triggers include:

Source:
National Institute of Neurological Disorders and Stroke
Migraine Update
http://www.ninds.nih.gov/disorders/migraine/migraine.htm (accessed on 24 July 2008).

Source:
Pace B, Glass RM.
Migraine Headache.
Journal of the American Medical Association. 2000; 284: 2672.

⁴

Lack of sleep
Hunger
Bright lights or loud noises
Anxiety
Stress
Certain foods, such as chocolate and some types of cheese
Some food additives, such as nitrites, nitrates and monosodium glutamate (MSG)
Coffee and some alcoholic beverages, such as red wine
Hormonal changes in women. For example, some women get migraine attacks when their period starts, when they are on the birth-control pill or when they are midway through their

menstrual cycle
A woman's periods are part of her menstrual cycle. This is the regular monthly pattern of events that causes an egg to be released from the ovaries so a woman can get pregnant and causes the bleeding that happens if she does not get pregnant.

menstrual cycle.
Changes in the weather, such as a change in barometric pressure.
Some prescribed medications

Why me?

If you get migraines, you may have inherited the tendency to get these attacks from one of your parents. This means that the tendency to get migraine attacks is in your

genes
Your genes are the parts of your cells that contain instructions for how your body works. Genes are housed on chromosomes, structures that sit in the nucleus at the middle of each of your cells. You have 23 pairs of chromosomes in your normal cells, each of which has thousands of genes. You get one set of chromosomes, and all of the genes that are on them, from each of your parents.

genes.

Genes are passed from parent to child. They program how you develop and how your body works. Research shows that certain genes may be linked to migraines. However, genes don't completely explain why some people get migraines.

For some people, there may be something in their environment or something that happens when they are growing up (such as having a certain illness) that causes migraines.

Source:
Breslau N, Rasmussen BK.
The impact of migraine: epidemiology, risk factors, and co-morbidities.
Neurology. 2001; 56 (supplement): S4-S12.

⁵ Researchers believe that having migraines with auras is more likely to be caused by genes than migraines without auras are.

Source:
Breslau N, Rasmussen BK.
The impact of migraine: epidemiology, risk factors, and co-morbidities.
Neurology. 2001; 56 (supplement): S4-S12.

⁵

Should I see my doctor?

You may want to see your doctor if:

Your symptoms don't get better using over-the-counter medication
Your migraine attacks have gotten worse and you get them more often
You are worried that something other than migraines may be causing your headaches (for example, if you have other symptoms)
You are not completely free of symptoms between attacks. Tell your doctor if, for example, part of your body feels numb or you have problems with your vision even when you are not having an attack.

Source:
Pace B, Glass RM.
Migraine Headache.
Journal of the American Medical Association. 2000; 284: 2672.

⁴

Source:
Drug and Therapeutics Bulletin.
Managing migraine.
Drug and Therapeutics Bulletin. 36(6):41-4, 1998 Jun.

⁶

Researchers have found that more than half of people who get migraine attacks use only over-the-counter medications. The researchers suggested that many people with migraine do not see their doctor about their headaches because they think that there aren't any treatments that work.

Source:
Mannix LK.
Epidemiology and impact of primary headache disorders.
Medical Clinics of North America. 2001; 85: 887-895.

⁷ But there are treatments that can help. One of the drugs known as triptans may work for you.

Sources for the information on this page:

Goadsby PJ, Lipton RB, Ferrari MD.Migraine: current understanding and treatment.New England Journal of Medicine. 2002; 346: 257-270.

Tepper SJ, Donnan GA, Dowson AJ, et al.A long-term study to maximise migraine relief with zolmitriptan.Current medical research and opinion. 1999; 15: 254-271.

National Institute of Neurological Disorders and StrokeMigraine Updatehttp://www.ninds.nih.gov/disorders/migraine/migraine.htm (accessed on 24 July 2008).

Pace B, Glass RM.Migraine Headache.Journal of the American Medical Association. 2000; 284: 2672.

Breslau N, Rasmussen BK.The impact of migraine: epidemiology, risk factors, and co-morbidities.Neurology. 2001; 56 (supplement): S4-S12.

Drug and Therapeutics Bulletin. Managing migraine.Drug and Therapeutics Bulletin. 36(6):41-4, 1998 Jun.

Mannix LK.Epidemiology and impact of primary headache disorders.Medical Clinics of North America. 2001; 85: 887-895.

This information was last updated on May 12, 2009

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