Acetaminophen and Hydrocodone
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Acetaminophen and Hydrocodone
(a set a mee' noe fen) (hye droe koe' done)

What makes the information on ConsumerReportsHealth.org different?
  • We do not rely simply on drug package inserts and manufacturer claims.
  • Our information about drug and safety, off-label uses, side effects and interactions is based on the best available clinical evidence -- the same information used by hospital pharmacists

Other names
Anexsia, Co-gesic, Lorcet-HD, Lortab, Norco, Panacet, Vicodin, Zydone,  APAP and Hydrocodone
Why is this medication prescribed?
This combination of drugs is used to relieve moderate to moderately severe pain.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medication be used?
The combination of acetaminophen and hydrocodone comes as a tablet, capsule, and liquid to take by mouth. It usually is taken every 4-6 hours as needed. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take acetaminophen and hydrocodone exactly as directed.
Hydrocodone can be habit-forming. Do not take a larger dose, take it more often, or for a longer period than your doctor tells you to.
What side effects can this medication cause?


Acetaminophen and hydrocodone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • lightheadedness
  • dizziness
  • drowsiness
  • upset stomach
  • vomiting
  • constipation
  • stomach pain
  • rash
  • difficulty urinating



If you experience either of the following symptoms, call your doctor immediately:

  • difficulty breathing
  • mood changes

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
What special precautions should I follow?
Before taking acetaminophen and hydrocodone,

  • tell your doctor and pharmacist if you are allergic to acetaminophen, codeine, hydrocodone, sulfite, or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially acetaminophen (Tylenol); antidepressants; medications for cough, cold, or allergies; other pain relievers; sedatives; sleeping pills; tranquilizers; and vitamins.
  • tell your doctor if you have or have ever had liver or kidney disease, a history of alcoholism, lung or thyroid disease, prostatic hypertrophy, or urinary retention.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking acetaminophen and hydrocodone, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking acetaminophen and hydrocodone.
  • you should know that this drug may make you drowsy and dizzy; do not drive a car or operate heavy machinery until you know how acetaminophen and hydrocodone affects you.
  • talk to your doctor about the safe use of alcohol. Alcohol may alter the effectiveness of acetaminophen and hydrocodone.
What should I do if I forget to take a dose?
This medication usually is taken as needed. If your doctor has told you to take acetaminophen and hydrocodone regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What storage conditions are needed for this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
What should I do in case of overdose?
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?
Keep all appointments with your doctor. If your pain is not controlled or continues, call your doctor.
Too much acetaminophen may cause liver damage; do not take more than 4000 mg of acetaminophen per day.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Last Revised March 2007