Gemtuzumab ozogamicin injection should be given in a hospital or medical facility under the supervision of a doctor who is experienced in treating people who have leukemia.

Gemtuzumab ozogamicin injection should not be given with other chemotherapy medications.

Gemtuzumab ozogamicin injection causes a severe decrease in the number of all types of blood cells in your blood. This may cause certain symptoms and may increase the risk that you will develop a serious infection. If you experience any of the following symptoms, call your doctor immediately: pale skin, excessive tiredness, shortness of breath, dizziness, fast heartbeat, unusual bruising or bleeding, nosebleeds, black or tarry stool, blood in the urine, excessive vaginal bleeding, or signs of infection such as sore throat, fever, cough, and chills.

Gemtuzumab ozogamicin injection may cause serious or fatal allergic reactions which usually occur during the infusion of the medication or within 24 hours of receiving a dose. The risk that you will experience a serious allergic reaction is greater if you have lung disease or if you have a large number of white blood cells in your blood. You may be given medication or other treatment to decrease the number of white blood cells in your blood before you receive gemtuzumab ozogamicin. You also may receive certain medications before and during your infusion to prevent an allergic reaction. Your doctor will watch you carefully while you are receiving gemtuzumab ozogamicin and for at least 4 hours afterward. If you experience any of the following symptoms, tell your doctor immediately: hives; rash; itching; swelling of the eyes, face, mouth, tongue, throat, arms, hands, feet, ankles, or lower legs; hoarseness; difficulty breathing or swallowing; shortness of breath; fast, breathing; wheezing; coughing; pale or bluish skin; anxiety or restlessness; excessive sweating; fever; or chills.

Gemtuzumab ozogamicin injection may cause serious or fatal liver damage. Tell your doctor if you have had or will be having a stem cell transplant (procedure that replaces diseased bone marrow with healthy bone marrow) and if you have or have ever had liver disease. If you experience any of the following symptoms, tell your doctor immediately: fast weight gain, pain in the upper right area of the stomach, swelling of the stomach, or yellowing of the skin or eyes.

Talk to your doctor about the risks of using gemtuzumab ozogamicin injection.