Influenza Vaccine, Live Intranasal
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Influenza Vaccine, Live Intranasal
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FluMist
Influenza (flu) is a contagious disease. It is caused by the influenza virus, which spreads from infected persons to the nose
or throat of others. Other illnesses can have the same symptoms and are often mistaken for influenza. But only an illness
caused by the influenza virus is really influenza.
Anyone can get influenza, but rates of infection are highest among children. For most people, it lasts only a few days. It
can cause: fever, sore throat, chills, fatigue, cough, headache, and muscle aches.
Some people get much sicker. Influenza can lead to pneumonia and can be dangerous for people with heart or breathing conditions.
It can cause high fever and seizures in children. On average, 226,000 people are hospitalized every year because of influenza
and 36,000 die - mostly elderly.
Influenza vaccine can prevent influenza.
There are two types of influenza vaccine:
- Live, attenuated influenza vaccine (LAIV) contains live but attenuated (weakened) influenza virus. It is sprayed into the nostrils rather than injected into the muscle.
- Inactivated influenza vaccine, sometimes called the ''flu shot,'' is given by injection. This vaccine is described in a separate monograph.
For most people influenza vaccine prevents serious influenza-related illness. But it will not prevent ''influenza-like'' illnesses
caused by other viruses.
Influenza viruses are always changing. Because of this, influenza vaccines are updated every year, and an annual vaccination
is recommended. Protection lasts up to a year.
It takes about 2 weeks for protection to develop after the vaccination.
LAIV does not contain thimerosal or other preservatives.
Live, intranasal influenza vaccine is approved for healthy people from 2 through 49 years of age, who are not pregnant. This
includes people who can spread influenza to others at high risk, such as:
- Household contacts and out-of-home caregivers of children from birth up to 5 years of age.
- Physicians and nurses, and family members or any one else in close contact with people at risk of serious influenza.
Influenza vaccine should be given to anyone who wants to reduce the likelihood of becoming ill with influenza or spreading
influenza to others. LAIV may be considered for:
- People who provide essential community services.
- People living in dormitories or under other crowded conditions, to prevent outbreaks.
LAIV is not licensed for everyone. The following people should check with their healthcare provider about getting the inactivated
vaccine (flu shot).
- Adults 50 years of age and older or children 6 months up to 2 years of age. (Children younger than 6 months cannot get either influenza vaccine.)
- Children younger than 5 with recurrent wheezing.
- People who have long-term health problems with heart disease; kidney disease; lung disease; metabolic disease, such as diabetes; asthma; anemia, and other blood disorders.
- Anyone with a weakened immune system.
- Children or adolescents on long-term aspirin treatment.
- Pregnant women.
- Anyone with a history of Guillain-Barré syndrome (a severe paralytic illness, also called GBS).
Inactivated influenza vaccine is the preferred vaccine for people (including healthcare workers, and family members) coming
in close contact with anyone who has a severely weakened immune system (that is, anyone who requires care in a protected environment).
Some people should talk with a doctor before getting either influenza vaccine:
- Anyone who has ever had a serious allergic reaction to eggs or another vaccine component, or to a previous dose of influenza vaccine.
- People who are moderately or severely ill should usually wait until they recover before getting flu vaccine. If you are ill, talk to your doctor or nurse about whether to reschedule the vaccination. People with a mild illness can usually get the vaccine.
Plan to get influenza vaccine in October or November if you can. But getting vaccinated in December, or even later, will still
be beneficial in most years. You can get the vaccine as soon as it is available, and for as long as illness is occurring.
Influenza illness can occur any time from November through May. Most cases usually occur in January or February.
Most people need one dose of influenza vaccine each year. Children younger than 9 years of age getting influenza vaccine for
the first time should get two doses. For LAIV, these doses should be given 6-10 weeks apart.
LAIV may be given at the same time as other vaccines.
A vaccine, like any medicine, could possibly cause serious problems, such as severe allergic reactions. However, the risk
of a vaccine causing serious harm, or death, is extremely small. Live influenza vaccine viruses rarely spread from person
to person. Even if they do, they are not likely to cause illness. LAIV is made from weakened virus and does not cause influenza.
The vaccine can cause mild symptoms in people who get it (see below).
Mild Problems (In children and adolescents 2-17 years of age):
- runny nose, nasal congestion or cough
- headache and muscle aches
- fever
- wheezing
- abdominal pain or occasional vomiting or diarrhea
Mild Problems (In adults 18-49 years of age):
- runny nose or nasal congestion
- cough, chills, tiredness/weakness
- sore throat
- headache
These symptoms did not last long and went away on their own. Although they can occur after vaccination, they may not have
been caused by the vaccine.
Severe Problems:
- Life-threatening allergic reactions from vaccines are very rare. If they do occur, it is within a few minutes to a few hours after the vaccination.
- If rare reactions occur with any new product, they may not be identified until thousands, or millions, of people have used it. Over six million doses of LAIV have been distributed since it was licensed, and no serious problems have been identified. Like all vaccines, LAIV will continue to be monitored for unusual or severe problems.
What should I look for?
- Any unusual condition, such as a high fever or behavior changes. Signs of a serious allergic reaction can include difficulty breathing, hoarseness or wheezing, hives, paleness, weakness, a fast heartbeat or dizziness.
What should I do?
- Call a doctor, or get the person to a doctor right away.
- Tell your doctor what happened, the date and time it happened, and when the vaccination was given.
- Ask your healthcare provider to file a Vaccine Adverse Event Reporting System (VAERS) form if you have any reaction to the vaccine. Or call VAERS yourself at 1-800-822-7967, or visit their website at http://vaers.hhs.gov.
In the rare event that you or your child has a serious reaction to a vaccine, a federal program has been created to help pay
for the care of those who have been harmed.
For details about the National Vaccine Injury Compensation Program, call 1-800-338-2382 or visit the program's website at
http://www.hrsa.gov/vaccinecompensation.
- Ask your doctor or other health care provider. They can give you the vaccine package insert or suggest other sources of information.
- Call your local or state health department's immunization program.
- Contact the Centers for Disease Control and Prevention (CDC): call 1-800-232-4636 (1-800-CDC-INFO) or visit the National Immunization Program's website at http://www.cdc.gov/vaccines.
Live Attenuated Influenza Vaccine Information Statement. U.S. Department of Health and Human Services/Centers for Disease
Control and Prevention National Immunization Program. 10/4/07.
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