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Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. Acetaminophen may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints). Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.
Acetaminophen comes as a tablet, chewable tablet, capsule, suspension or solution (liquid), drops (concentrated liquid), extended-release (long-acting) tablet, and orally disintegrating tablet (tablet that dissolves quickly in the mouth), to take by mouth, with or without food. Acetaminophen also comes as a suppository to use rectally. Acetaminophen is available without a prescription, but your doctor may prescribe acetaminophen to treat certain conditions. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take acetaminophen exactly as directed. Do not take more or less of it or take it more often than directed on the package label or prescribed by your doctor. Taking more than the recommended amount may cause damage to your liver.
If you are giving acetaminophen to your child, read the package label carefully to make sure that it is the right product for the age of the child. Do not give children acetaminophen products that are made for adults. Some products for adults and older children may contain too much acetaminophen for a younger child. Drops made for infants are more concentrated (much more medication in each drop) than liquids made for older children. Check the package label to find out how much medication the child needs. If you know how much your child weighs, give the dose that matches that weight on the chart. If you don't know your child's weight, give the dose that matches your child's age. Ask your child's doctor if you don't know how much medication to give your child.
Acetaminophen comes in combination with other medications to treat cough and cold symptoms. Ask your doctor or pharmacist for advice on which product is best for your symptoms. Check nonprescription cough and cold product labels carefully before using two or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose. This is especially important if you will be giving cough and cold medications to a child.
Swallow the extended-release tablets whole; do not split, chew, crush, or dissolve them.
Place the orally disintegrating tablet ('Meltaways') in your mouth and allow to dissolve or chew it before swallowing.
Shake the suspension and drops well before each use to mix the medication evenly. Use the measuring cup provided by the manufacturer to measure each dose of the solution or suspension, and use the dosing device provided to measure each dose of the drops. Use the dosing device to slowly release the drops directly into the child's mouth near the inner cheek. Do not mix the drops with baby formula.
To insert an acetaminophen suppository into the rectum, follow these steps:
- Remove the wrapper.
- Dip the tip of the suppository in water.
- Lie down on your left side and raise your right knee to your chest. (A left-handed person should lie on the right side and raise the left knee.)
- Using your finger, insert the suppository into the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeters) in infants and children and 1 inch (2.5 centimeters) in adults. Hold it in place for a few moments.
- Stand up after about 15 minutes. Wash your hands thoroughly and resume your normal activities.
Stop taking acetaminophen and call your doctor if your symptoms get worse, you develop new or unexpected symptoms, including redness or swelling, your pain lasts for more than 10 days, or your fever gets worse or lasts more than 3 days. Also stop giving acetaminophen to your child and call your child's doctor if your child develops new symptoms, including redness or swelling, or your child's pain lasts for longer than 5 days, or fever get worse or lasts longer than 3 days.
Do not give acetaminophen to a child who has a sore throat that is severe or does not go away, or that occurs along with fever, headache, rash, nausea, or vomiting. Call the child's doctor right away, because these symptoms may be signs of a more serious condition.
Acetaminophen may also be used in combination with aspirin and caffeine to relieve the pain associated with migraine headache.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
- Acephen®
- Allerest® No Drowsiness (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Anacin® Aspirin Free Maximum Strength Tablets®
- Axocet® (as a combination product containing Acetaminophen and Butalbital)
- Benadryl® Severe Allergy and Sinus Headache Maximum Strength Caplets® (as a combination product containing Acetaminophen, Diphenhydramine Hydrochloride, and Pseudoephedrine Hydrochloride)
- Bupap® (as a combination product containing Acetaminophen and Butalbital)
- Capital® and Codeine
- Dristan® Cold No Drowsiness Formula Maximum Strength Caplets® (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Duradrin® (as a combination product containing Acetaminophen, Dichloralphenazone, and Isometheptene Mucate)
- Endocet®
- Excedrin® Aspirin-Free Caplets® (as a combination product containing Acetaminophen and Caffeine)
- Excedrin® Aspirin-Free Geltabs® (as a combination product containing Acetaminophen and Caffeine)
- Excedrin® Extra-Strength Caplets®
- Excedrin® Extra-Strength Tablets
- Excedrin® Migraine Caplets®
- Excedrin® Migraine Geltabs
- Excedrin® Migraine Tablets
- Excedrin® Quicktabs® (as a combination product containing Acetaminophen and Caffeine)
- Excedrin P.M.® Caplets®
- Excedrin P.M.® Geltabs®
- Excedrin P.M.® Tablets
- FeverAll®
- FeverAll® Infants'
- FeverAll® Junior Strength
- Gelpirin®
- Genapap®
- Genapap® Children's
- Genapap® Drops Infant's
- Genapap® Extra Strength Caplets®
- Genapap® Extra Strength Tablets
- Genapap® Gel-Coat Caplets®
- Genebs®
- Genebs® Extra Strength Caplets®
- Genebs® Extra Strength Tablets
- Goody's® Extra Strength Tablets
- Goody's® Fast Pain Relief Tablets
- Goody's® Headache Powders
- I.D.A.® (as a combination product containing Acetaminophen, Dichloralphenazone, and Isometheptene Mucate)
- Liquiprin® Drops
- Midol® Menstrual Formula Maximum Strength Caplets® (as a combination product containing Acetaminophen, Caffeine, and Pyrilamine Maleate)
- Midol® Menstrual Formula Maximum Strength Gelcaps® (as a combination product containing Acetaminophen, Caffeine, and Pyrilamine Maleate)
- Midol® PMS Maximum Strength Caplets® (as a combination product containing Acetaminophen, Pamabrom, and Pyrilamine Maleate)
- Midol® PMS Maximum Strength Gelcaps® (as a combination product containing Acetaminophen, Pamabrom, and Pyrilamine Maleate)
- Midol® Teen Menstrual Formula Caplets® (as a combination product containing Acetaminophen and Pamabrom)
- Midrin® (as a combination product containing Acetaminophen, Dichloralphenazone, and Isometheptene Mucate)
- Ornex® Caplets® (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Ornex® Maximum Strength Caplets® (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Pamprin® Maximum Pain Relief Caplets® (as a combination product containing Acetaminophen, Magnesium Salicylate, and Pamabrom)
- Pamprin® Multi-Symptom (as a combination product containing Acetaminophen, Pamabrom, and Pyrilamine Maleate)
- Percogesic® (as a combination product containing Acetaminophen and Phenyltoloxamine Citrate)
- Percogesic® Extra Strength Caplets® (as a combination product containing Acetaminophen and Diphenhydramine Hydrochloride)
- Phrenilin® (as a combination product containing Acetaminophen and Butalbital)
- Phrenilin® Forte (as a combination product containing Acetaminophen and Butalbital)
- Premsyn PMS® Caplets® (as a combination product containing Acetaminophen, Pamabrom, and Pyrilamine Maleate)
- Roxicet®
- Sedapap® (as a combination product containing Acetaminophen and Butalbital)
- Sinarest® No Drowsiness Tablets (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Sine-Off® Maximum Strength No Drowsiness Formula Caplets® (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Sinutab® (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Sinutab® Sinus Medication Maximum Strength Without Drowsiness Tablets (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Sominex® Pain Relief Formula (as a combination product containing Acetaminophen and Diphenhydramine Hydrochloride)
- St. Joseph® Cold Tablets for Children (as a combination product containing Acetaminophen and Phenylpropanolamine Hydrochloride)
- Sudafed® Sinus & Headache Caplets® (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Sudafed® Sinus & Headache Maximum Strength Tablets (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Supac®
- Tylenol®
- Tylenol® Allergy Sinus NightTime Maximum Strength Caplets® (as a combination product containing Acetaminophen, Diphenhydramine Hydrochloride, and Pseudoephedrine Hydrochloride)
- Tylenol® Arthritis Pain Extended Relief Caplets®
- Tylenol® Concentrated Drops Infant's
- Tylenol® Extra Strength ®
- Tylenol® Extra Strength Adult
- Tylenol® Extra Strength Gelcaps®
- Tylenol® Extra Strength Geltabs®
- Tylenol® Extra Strength Tablets
- Tylenol® Flu NightTime Maximum Strength Gelcaps® (as a combination product containing Acetaminophen, Diphenhydramine Hydrochloride, and Pseudoephedrine Hydrochloride)
- Tylenol® Meltaways
- Tylenol® Meltaways Junior Strength
- Tylenol® PM Extra Strength Caplets® (as a combination product containing Acetaminophen and Diphenhydramine Hydrochloride)
- Tylenol® PM Extra Strength Gelcaps® (as a combination product containing Acetaminophen and Diphenhydramine Hydrochloride)
- Tylenol® PM Extra Strength Geltabs® (as a combination product containing Acetaminophen and Diphenhydramine Hydrochloride)
- Tylenol® Sinus Geltabs® Maximum Strength Tablets (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Tylenol® Sinus Medication Maximum-Strength Caplets® (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Tylenol® Sinus Medication Maximum-Strength Gelcaps® (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Tylenol® Sinus Medication Maximum Strength Geltabs® (as a combination product containing Acetaminophen and Pseudoephedrine Hydrochloride)
- Tylenol® Suspension Children's
- Tylenol® with Codeine Elixir
- Tylenol® with Codeine No. 3
- Tylenol® with Codeine No. 4
- Tylenol® Women's Caplets® (as a combination product containing Acetaminophen and Pamabrom)
- Tylox®
- Ultracet® (as a combination product containing Acetaminophen and Tramadol Hydrochloride)
- Vanquish® Caplets®
- Women's Tylenol® Menstrual Relief Caplets® (as a combination product containing Acetaminophen and Pamabrom)
- Wygesic®
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