How is it used?

Before taking

While taking

Warnings

Your doctor has ordered hydroxyurea to help treat your illness. Hydroxyurea comes as a capsule to take by mouth.

This medication is used:

• to treat melanoma (a type of skin cancer)
• to treat chronic myelocytic leukemia (CML; cancer of the white blood cells)
• to treat recurrent, metastatic, or inoperable ovarian cancer [cancer of the ovary (a female reproductive organ) that has returned after treatment, that has spread, or that cannot be treated with surgery]
• with radiation therapy to control primary squamous cell carcinoma (a type of skin cancer) that affects any part of the head or neck except the lips
• to prevent crises (episodes of severe pain) and decrease the need for blood transfusions (transfer of one person's blood to another person's body) in people who have sickle cell anemia (a blood disease that may cause painful crises, a low number of red blood cells, infection, and damage to the internal organs).

Hydroxyurea is in a class of medications known as antineoplastic agents.Hydroxyurea treats cancer by slowing or stopping the growth of cancer cells. Hydroxyurea treats sickle cell anemia by changing red blood cells so that they are less likely to bend in an abnormal shape. The length of treatment depends on the condition you have and how well your body responds to this medication.

Hydroxyurea is usually taken once a day. When hydroxyurea is used to treat certain types of cancer, it may be taken once every third day. Try to take hydroxyurea at about the same time of day on the days that you are scheduled to take the medication. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain anything you do not understand. Take hydroxyurea exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of hydroxyurea and gradually increase your dose.

Hydroxyurea may help control the symptoms of sickle cell anemia but does not cure the condition. Continue to take hydroxyurea even if you feel well. Do not stop taking this medication without talking to your doctor.

If you forget to take a dose of hydroxyurea, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed dose and do not take more than one dose in one day. Call your doctor if you miss more than one dose of hydroxyurea.

Hydroxyurea is also sometimes used to treat polycythemia vera (a condition in which the body produces too many blood cells), psoriasis (a skin disease in which red, scaly patches form on some areas of the body), and hypereosinophilic syndrome (a condition in which the body produces too many of a certain type of white blood cell). Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

This information being provided is copyrighted by the American Society of Health-System Pharmacists, Inc., ASHP, Bethesda, Maryland.
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