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Pimozide (pi' moe zide)
Other names: Orap
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Why is this medication prescribed?

Pimozide is used to control motor or verbal tics (an uncontrollable need to repeat certain movements or sounds) caused by Tourette's disorder (condition characterized by motor or verbal tics). Pimozide should only be used to treat people who cannot take other medications or who have taken other medications without good results. Pimozide should only be used to treat severe tics that stop the person from learning, working, or performing daily activities.

Pimozide is in a class of medications called conventional antipsychotics. It works by decreasing abnormal excitement in the brain.

How should this medication be used?

Pimozide comes as a tablet to take by mouth. It is usually taken once a day at bedtime or two or more times a day. Take pimozide at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pimozide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of pimozide and gradually increase your dose, not more than once every 2 or 3 days. Your doctor may decrease your dose once your condition is controlled. Be sure to tell your doctor how you are feeling during your treatment with pimozide.

Pimozide controls Tourette's disorder but does not cure it. It may take some time before you feel the full benefit of pimozide. Continue to take pimozide even if you feel well. Do not stop taking pimozide without talking to your doctor. If you suddenly stop taking pimozide, you may experience difficulty controlling your movements. Your doctor will probably decrease your dose gradually.

Are there other uses for this medicine?

Pimozide is also used sometimes to treat schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions) and certain behavior, personality, movement, and psychiatric disorders in adults. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; talk to your doctor or pharmacist for more information.

  • Orap®
Last Revised January 11, 2008
American Society of Health-System Pharmacists
This information being provided is copyrighted by the American Society of Health-System Pharmacists, Inc., ASHP, Bethesda, Maryland.
©2009. All Rights Reserved.
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