All three rows have plenty of room, with seating for up to eight. Optional second-row lounge chairs even have built-in footrests, but they look more comfortable than they really are. Interior quality and noise isolation took a step back, but the composed ride and refined powertrain remains. Fuel economy from the lively 3.5-liter V6 is a relatively good 20 mpg. Handling is responsive and secure. This version of the Sienna is the only minivan among its competitors to offer all-wheel-drive, at a sacrifice of one mpg. Model year 2015 updates included simplified controls and an updated infotainment system. Advanced safety gear, like forward-collision warning, is optional on high-end trims. 2017 updates included a new eight-speed automatic that replaced the six-speed.

Composed and quiet, the Sienna is more refined than rival minivans. Cabin ambiance matches that of some luxury sedans. Handling is sound and secure but not very agile. All-wheel-drive was an exclusive option; earlier versions had run-flat tires that were prone to fast wear. Power originally came from a refined 3.3-liter V6, while 2007 brought a 3.5-liter V6 with better acceleration and the same 19 mpg overall. AWD subtracts one mpg overall. Front- and middle-row seats are very comfortable; all three rows are easy to access. Stability control was optional on early models, and standard on all-wheel-drive versions. This vital safety feature became standard on all Siennas for 2008.