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Is it safe to regularly take Tylenol PM?

Long-term use isn't a good idea. It contains two medications - the pain reliever acetaminophen and an antihistamine (diphenhydramine) to help with insomnia. High doses of acetaminophen can cause liver damage. Possible side effects of diphenhydramine include daytime sleepiness and confusion, and it can worsen your sleeping problems when taken too often. Read on to see what we recommend instead.

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