Spacious seating for eight is a highlight, with one of the few third-row seats that can comfortably fit three adults across. Potent power comes from the top engine choice, a 5.7-liter V8 that supplies brisk acceleration. At 15 mpg overall, fuel economy is respectable for its class, but still isn't great. Smaller and refined V8s are also available. Handling is clumsy and even though the ride was improved, it still feels like a truck to drive. Off-road capability is impressive. Controls are simple to use, but it's a long reach to some of the radio controls across the wide cabin. A long-overdue 2016 update brought more modern infotainment and available blind spot monitoring. Overall though, the Sequoia feels dated next to more modern competition.

However, the Toyota isn't quite as roomy, nor can it tow as much as domestic full-sized competitors. Full-time 4WD is available, but it is a less sophisticated system than that found in Toyota's other large SUV, the Land Cruiser. Even though Toyotas are known for their refinement, the Sequoia has a relatively stiff ride. Handling is cumbersome, but the interior is well finished. Stability control became standard for 2004; it was previously optional.