Epilepsy drug Topamax poses risk of birth defects

The anti-seizure drug topiramate (Topamax and generic) might cause cleft lips and palates in children born to women who take the medication while pregnant, according to a new warning from the Food and Drug Administration. Topamax treats epileptic seizures and is also approved for migraine prevention. It's also prescribed off-label by some doctors to treat alcohol dependence, and, in some cases, as a weight-loss aid.

The drug will now be labeled as as a Class D drug, meaning there's evidence of  fetal risk in humans, according to the FDA. If you're a woman with epilepsy of childbearing age, talk with your doctor about other alternatives before agreeing to take the medication. It is important that women avoid seizures during pregnancy, so in certain situations the potential benefit of the drug may outweigh the risks.

—Maggie Shader