Q. The mattress in my guest room is a pillowtop bed that can’t be flipped. What’s the best way to clean it before my guests arrive for the holidays?

A. Even if your mattress is unflippable, there are simple steps you can take to help keep it clean and fresh.

First, remove any pads or covers and clean them according to the directions. Then vacuum the mattress with the upholstery attachment on your vacuum cleaner. Switch to the crevice tool for deep cleaning of seams, where dirt, dust, and undesirables collect.

A normal vacuum is fine, says John Galeotafiore, who led our recent vacuum tests, but if you’re a stickler, try the Dyson V6 Mattress Handheld Vacuum, $250. Although it’s a bit pricey, this Dyson sucked up three times more material from a mattress than a highly rated canister vacuum.

Don’t forget to spot-treat any stains. A carpet cleaner or enzyme-based pet-odor remover can do the job on bodily fluids. Then deodorize the mattress by sprinkling a box of baking soda over it. For best results, leave it on for 24 hours. Last, vacuum the mattress once again and put on clean sheets.

For more information, read "How to Clean a Mattress (and Why). Also check our mattress buying guide and ratings and vacuum cleaner buying guide and ratings.

You can send your questions to ConsumerReports.org/askourexperts.

Editor's Note: This article also appeared in the December 2016 issue of Consumer Reports magazine.